Carpagnano GE, et al. Looking for Airways Periostin in Severe Asthma: Could It Be Useful for Clustering Type 2 Endotype? Chest. 2018 Nov;154(5):1083-1090.
BACKGROUND: Severe asthma is heterogeneous clinically and biologically and is often difficult to control. In particular, the type 2 (T2) immunity endotype of severe asthma is gaining increasing interest because it is susceptible to newly developed biologic treatments that can transform the quality of life of these patients. The aim of this study was to analyze periostin concentrations in the airways of patients with severe asthma, evaluating its role in clustering the T2 endotype.