Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill. (Newman)

Angurana SK, et al. Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial. Crit Care Med. 2018 Oct;46(10):1656-1664.

OBJECTIVES: To evaluate the effect of probiotics on cytokines in children with severe sepsis.

DESIGN: Randomized, double-blind, placebo-controlled trial.

SETTING: ICU of a tertiary care teaching hospital in North India.

PATIENTS: Children 3 months to 12 years old with severe sepsis.

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Viral DNAemia and Immune Suppression in Pediatric Sepsis. (Lima)

Davila S, et al. Viral DNAemia and Immune Suppression in Pediatric Sepsis. Pediatr Crit Care Med. 2018 Jan;19(1):e14-e22

OBJECTIVES: Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk.

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Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality. (Colman)

Lyons PG, et al. Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality. Crit Care Med. 2018 May;46(5):736-742.

OBJECTIVES: To assess whether sepsis-associated coagulopathy predicts hospital mortality.

DESIGN: Retrospective cohort study.

SETTING: One-thousand three-hundred beds urban academic medical center.

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Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock. (Shildt)

Pruinelli L, et al. Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock. Crit Care Med. 2018 Apr;46(4):500-505.

OBJECTIVES: To specify when delays of specific 3-hour bundle Surviving Sepsis Campaign guideline recommendations applied to severe sepsis or septic shock become harmful and impact mortality.

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