Angurana SK, et al. Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial. Crit Care Med. 2018 Oct;46(10):1656-1664.
OBJECTIVES: To evaluate the effect of probiotics on cytokines in children with severe sepsis.
DESIGN: Randomized, double-blind, placebo-controlled trial.
SETTING: ICU of a tertiary care teaching hospital in North India.
PATIENTS: Children 3 months to 12 years old with severe sepsis.
Davila S, et al. Viral DNAemia and Immune Suppression in Pediatric Sepsis. Pediatr Crit Care Med. 2018 Jan;19(1):e14-e22
OBJECTIVES: Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk.
Lyons PG, et al. Sepsis-Associated Coagulopathy Severity Predicts Hospital Mortality. Crit Care Med. 2018 May;46(5):736-742.
OBJECTIVES: To assess whether sepsis-associated coagulopathy predicts hospital mortality.
DESIGN: Retrospective cohort study.
SETTING: One-thousand three-hundred beds urban academic medical center.
Pruinelli L, et al. Delay Within the 3-Hour Surviving Sepsis Campaign Guideline on Mortality for Patients With Severe Sepsis and Septic Shock. Crit Care Med. 2018 Apr;46(4):500-505.
OBJECTIVES: To specify when delays of specific 3-hour bundle Surviving Sepsis Campaign guideline recommendations applied to severe sepsis or septic shock become harmful and impact mortality.
Pediatric Critical Care Evidence 