Category Archives: Critical Care Medicine

Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study

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Shein SL, Maddux AB, Klein MJ, Bhalla A, Briassoulis G, Dahmer MK, Emeriaud G, Flori HR, Gedeit R, Ilia S, Kneyber MCJ, Napolitano N, Ohshimo S, Pons-Òdena M, Rubin S, White BR, Yehya N, Khemani R, Smith L; V4 PARDIE Investigators and the PALISI Network. Epidemiology and Outcomes of Critically Ill Children at Risk for Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study. Crit Care Med. 2021 Sep 27. doi: 10.1097/CCM.0000000000005287. Epub ahead of print. PMID: 34582416.

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Abstract
Objectives: Interventional trials aimed at pediatric acute respiratory distress syndrome prevention require accurate identification of high-risk patients. In this study, we aimed to characterize the frequency and outcomes of children meeting “at risk for pediatric acute respiratory distress syndrome” criteria as defined by the Pediatric Acute Lung Injury Consensus Conference. Continue reading →

Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. (Cory)

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Faustino EVS, et al. Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. Crit Care Med. 2019 May;47(5) :706-714.

OBJECTIVES: Previous studies report worse short-term outcomes with hypoglycemia in critically ill children. These studies relied on intermittent blood glucose measurements, which may have introduced detection bias. We analyzed data from the Heart And Lung Failure-Pediatric INsulin Titration trial to determine the association of hypoglycemia with adverse short-term outcomes in critically ill children.

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Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill. (Newman)

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Angurana SK, et al. Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial. Crit Care Med. 2018 Oct;46(10):1656-1664.

OBJECTIVES: To evaluate the effect of probiotics on cytokines in children with severe sepsis.

DESIGN: Randomized, double-blind, placebo-controlled trial.

SETTING: ICU of a tertiary care teaching hospital in North India.

PATIENTS: Children 3 months to 12 years old with severe sepsis.

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Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock. (Chaudhary)

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Woolum JA, et al. Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock. Crit Care Med. 2018 Jul 18. [Epub ahead of print]

OBJECTIVES: Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis that critically ill patients with septic shock exposed to thiamine would demonstrate improved lactate clearance and more favorable clinical outcomes compared with those not receiving thiamine.

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