Harvey V, Perrone J, Kim P. Does the use of tranexamic acid improve trauma mortality? Ann Emerg Med. 2013 Oct 3. doi:pii: S0196-0644(13)01341-3.
BOTTOM LINE: According to the available evidence, tranexamic acid has been shown to significantly decrease mortality in bleeding trauma patients, with no significant increase in serious prothrombotic complications if administered within 3 hours of injury. There is, however, no evidence of benefit in patients with traumatic brain injury. As such, we recommend early treatment with tranexamic acid in trauma patients without isolated brain injuries who have or are at risk for significant hemorrhage and in patients who receive resuscitation with blood products, particularly if they require massive transfusion or have a high risk of death at baseline.